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Fap-1 Antibody (H-300) is a rabbit polyclonal IgG

  • Fap-1 Antibody (H-300) is a rabbit polyclonal IgG provided at 200 µg/ml
  • epitope corresponding to amino acids 1-300 of Fap-1 of human origin
  • recommended for detection of Fap-1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
  • See 12 citations for Fap-1 Antibody (H-300)

In contrast to the growth factors which promote cell proliferation, FAS ligand (FAS-L) and the tumor necrosis factors (TNFs) rapidly induce apoptosis. Cellular response to FAS-L and TNF is mediated by structurally-related receptors containing a conserved “death domain” belonging to the TNF receptor superfamily. Putative downstream receptors of FAS include TRADD, FADD and RIP. A novel protein tyrosine phosphatase, Fap-1 (for FAS-associated phosphatase) (originally designated PTP-BAS), has been shown to associate with the carboxy terminus fifteen amino acids of FAS. Three isoforms of the protein result from alternative RNA splicings, the longest of which encodes a protein 2485 amino acids in length. Although lacking a transmembrane region, Fap-1 does contain a membrane-binding domain, similar to that found in cytoskeleton-associated proteins such as ezrin. Fap-1 does not seem to associate with CD40 or death domain proteins such as TNF-RI and TNF-RII.

Информация для заказа:

Область использования:Производство:Santa Cruz
Метод: 
Объем:200 мкг/мл 
Кат. номер:sc-15356
Цена (с НДС 20%): В корзину Добавить в корзину
Fap-1 Antibody (H-300) is a rabbit polyclonal IgGНаименование: Fap-1 Antibody (H-300) is a rabbit polyclonal IgG.
Примечание: SQ Category: Primary Antibodies,
Species: m, r, h,
Host Origin: human,
Applications: WB, IP, IF, IHC(P), ELISA,
UNSPSC: 12352203,
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