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TNF-R1 (H-5) / TNF-R1 Antibody (H-5) is a mouse monoclonal IgG2b

• TNF-R1 Antibody (H-5) is a mouse monoclonal IgG_2b provided at 200 µg/ml
• raised against amino acids 30-301 mapping within the extracellular domain of TNF-R1 of human origin
• recommended for detection of TNF-R1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
• See 65 citations for TNF-R1 Antibody (H-5)

Tumor necrosis factor (TNF) is a pleiotropic cytokine whose function is mediated through two distinct cell surface receptors (1). These receptors, designated TNF-R1 and TNF-R2, are expressed on most cell types (1,2). The majority of TNF functions are primarily mediated through TNF-R1, while signaling through TNF-R2 occurs less extensively and is confined to cells of the immune system (1). Both of these proteins belong to the growing TNF and nerve growth factor (NGF) receptor superfamily, which includes FAS, CD30, CD27 and CD40 (3). The members of this superfamily are type I membrane proteins that share sequence homology confined to the extracellular region (2). TNF-R1 shares a motif coined the “death domain” with FAS and three structurally unrelated signaling proteins, TRADD, FADD and RIP (1,3–8). This “death domain” is required for transduction of the apoptotic signal (9).

Информация для заказа:

Область использования: Антитела к мембранным рецепторам Антитела к мембранным рецепторам для вестерн-блоттинга Антитела к мембранным рецепторам для иммунопреципитации Антитела к мембранным рецепторам для иммунофлуоресценции Первичные антитела и конъюгаты	Производство:	Santa Cruz
	Метод:
	Объем:	200 мкг/мл
	Кат. номер:	sc-8436
Цена (с НДС 20%):		В корзину
Наименование: TNF-R1 (H-5) / TNF-R1 Antibody (H-5) is a mouse monoclonal IgG2b. Примечание: SQ Category: Primary Antibodies, Species: m, r, h, Host Origin: human, Applications: WB, IP, IF, IHC(P), ELISA, UNSPSC: 12352203, datasheet