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Neu Antibody (9G6) is a mouse monoclonal IgG1 / Антитела мышиные моноклональные к Neu (9G6)

  • Neu Antibody (9G6) is a mouse monoclonal IgG1 provided at 100 µg/ml
  • epitope mapping within an extracellular domain of Neu of human origin
  • recommended for detection of Neu gp185 of human origin by IP, IF, IHC(P) and FCM
  • partial inhibition of protein tyrosine kinase activit

The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3), and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Neu, a glycoprotein, undergoes transactivation upon hetero-dimerization with other EGF receptor family members. Neu heterodimerization with ErbB-3 recruits heregulin, which induces phosphoinositide (PI) 3-kinase activation. Activation of Neu potentiates tumor cell motility and protease secretion and invasion, and also modulates cell cycle checkpoint function, DNA repair and apoptotic responses. Amplification and/or overexpression of Neu occurs in 20-30% of breast carcinomas. Measurement of increased Neu expression can be a predictor of disease prognosis. Neu may also prove to be a promising target for therapeutic agents.

Информация для заказа:

Область использования:Производство:Santa Cruz
Метод: 
Объем:100 мкг/мл 
Кат. номер:sc-08
Цена (с НДС 20%): В корзину Добавить в корзину
Neu Antibody (9G6) is a mouse monoclonal IgG1 / Антитела мышиные моноклональные к Neu (9G6)Наименование: Neu Antibody (9G6) is a mouse monoclonal IgG1 / Антитела мышиные моноклональные к Neu (9G6).
Примечание: SQ Category: Primary Antibodies,
Species: human,
Host Origin: human,
Applications: IP, IF, IHC(P), FCM,
UNSPSC: 12352203,
datasheet
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